3D ‘mini-retinas’ Grown from Mouse and Human Stem Cells

Stem cell science has progressed so that researchers can now share recipes for making human retinas; the part of the eye that is sensitive to light. The first protocols enabled the generation of retinal cells in laboratory plates and more recently as complex tissue in the form of tiny eye-like cups. Researchers in Germany now have another efficient way to make 3D retina organoids, which mimic the organ’s tissue organization, from mouse or human stem cells. Their version of "mini-retinas", published online on March 31 by Stem Cell Reports, offers new perspectives on retina growth, injury, and repair.

"mini-retinas" - The image shows two developing eyefield tissues growing out of a seven-day-old cell aggregate generated from mouse embryonic stem cells, which subsequently give rise to 3D stratified retinal organoids. Eyefields are revealed by immunostaining for the eyefield transcription factors RAX and LHX2 shown in red and green colors, respectively, and cell nuclei are counterstained by DAPI (grey). CREDIT Manuela V
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