New fertility treatment, CATI (Cognitive automation of time-lapse images) which is the first automated system for using artificial intelligence to recognise and sort embryos, has been launched by The Prague Fertility Centre.
The system, which sorts embryos according to selected morphokinetic criteria, obtained from time-lapse systems plays an important role in IVF with aneuploidy screening (PGS) in preventing the misdiagnosis of mosaic embryos.
Pioneered by Mr Daniel Hlinka, the co-owner and Head Embryologist at The Prague Fertility Centre, CATI, combined with PGS boosts success rates by 30-40%. This means that for example a woman aged 40, who has a 20% chance of pregnancy, will reach the rates of a younger woman, with 50-60% chance of success.
Mr Hlinka, who has been at the forefront of fertility advancements during his career, says: “Preimplantation genetic screening (PGS) is a screening tool that is being used to help further improve embryo selection and is successful. However, there is a drawback with this method in that false negative/positive results can occur in mosaic embryos, leading to the rejection of viable embryos.
“CATI removes this disadvantage by detecting abnormal cleavage patterns and providing valuable information on the dynamics of the embryo morphologic changes, so that only viable embryos are used. The automatic statistic analysis enables the evaluation of multiple embryo markers at the same time to remove human error and only select those that are relevant to embryo implantation ability.
“It is the use of both PGS and CATI together which is aiding the goal of IVF and leading to increased success rates of a healthy live birth.”
A recent study* showed a significant difference in clinical pregnancy rates between ‘Group A’ patients that had embryos undergo time-lapse and PGS, and ‘Group B’ patients that had embryos cultured in time-lapse alone, (72.5% vs 52.6%, respectively). For ongoing pregnancy rates, a significant difference was also observed between the two groups (71.6% for Group A vs 50.8% for Group B).
Mr Hlinka adds, “All couples with at least one parameter of their reproductive ability affected can benefit from the combined technique of using PGS and CATI. This includes those who have experienced multiple miscarriages, repeated failure of implantation or those who have an advanced reproductive age.”
This new treatment is available at The Prague Fertility Centre, a private fertility clinic based in Prague, which brings the most recent scientific findings into practice alongside top professionals and the latest technology advances.
The Prague Fertility Centre exhibited at the London Fertility Show.
Source: The Prague Fertility Centre